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danazol will boost the amount or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.

saquinavir will enhance the degree or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

indinavir will enhance the level or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

Study all affected person information and facts, medication guides, and instruction sheets delivered to you personally. Talk to your physician or pharmacist Should you have any thoughts.

It is illegal to import modafinil to The usa without a Drug Enforcement Administration (DEA)-registered importer and also a prescription.[204] Men and women could legally convey modafinil to the US from a overseas region for private use, restricted to fifty dosage units, using a prescription and correct declaration within the border.

sparsentan will reduce the level or result of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Watch. Sparsentan (a CYP2C19 inducer) decreases publicity of CYP2C19 substrates and lessens efficacy associated with these substrates.

Voxelotor raises systemic publicity of sensitive CYP3A4 substrates. Keep away from coadministration with delicate CYP3A4 substrates using a slender therapeutic index. Consider dose reduction on the delicate CYP3A4 substrate(s) if unable to keep away from.

crofelemer will increase amounts of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Crofelemer has the prospective to inhibit CYP3A4 at concentrations predicted during the intestine; not likely to inhibit systemically for the reason that minimally absorbed.

Check Closely (1)levoketoconazole will raise the amount or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

Consider this medicine concurrently day after day. Will not change the time of day you take modafinil without the need of conversing 1st together with your medical doctor. You could consider this drugs with or devoid of foods. Dosing The dose of this read more drugs is going to be distinct for various sufferers. Follow your health care provider's orders or perhaps the directions to the label. The next information incorporates only the typical doses of the medication. If your dose is different, do not transform it Unless of course your doctor informs you to do so.

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Blood levels of cyclosporine might be lowered when employed with PROVIGIL. Monitoring of circulating cyclosporine concentrations and acceptable dosage adjustment for cyclosporine must be viewed as when applied concomitantly with PROVIGIL.

While modafinil is mostly found to get safe and important adverse effects are unusual, including in pediatric narcolepsy circumstances (slumber Problems in little ones), There's proof that extended-time period usage can cause tolerance in certain people.